HybridCN-NAS: Multi-Stage Deep Learning for Leukemia Cell Classification

Algorithm Workflow

Our multi-stage deep learning pipeline for leukemia cell classification

HybridCN-NAS: Multi-Stage Deep Learning for Leukemia Cell Classification Workflow
Download Image

Methodology & Approach

Detailed breakdown of our multi-stage deep learning approach

1

Stage 1: Cell Segmentation

Attention U-Net for precise cell boundary detection

Multi-scale attention mechanisms for improved segmentation accuracy

Post-processing for noise reduction and boundary refinement

2

Stage 2: Feature Extraction (HybridCN-NAS)

ConvNeXt Large backbone for robust feature representation

NASNet Large integration for architecture optimization

Multi-scale feature fusion from both networks

Deep feature extraction capturing cellular morphology

3

Stage 3: Feature Normalization & Selection

Z-score normalization for feature standardization

mRMR (minimum Redundancy Maximum Relevance) feature selection

Selection of top discriminative features for classification

Dimensionality reduction to enhance model performance

4

Stage 4: Classification & Visualization

Multi-Head Self-Attention classifier for final prediction

Grad-CAM visualization for explainable predictions

Probabilistic output with confidence estimation

Four-class classification: Benign, Early, Pre, Pro

Key Innovations

Novel contributions and technological advances in our approach

HybridCN-NAS architecture combining ConvNeXt and NASNet

Attention U-Net for precise cell segmentation

Multi-head self-attention for robust classification

Grad-CAM for explainable AI and clinical interpretability and feature selection using mRMR

Technical Architecture

Deep learning components and model architecture details

Cell Segmentation

Attention U-Net

Advanced segmentation network with attention mechanisms for precise cell boundary detection

Multi-scale Processing

Hierarchical feature extraction at multiple scales for comprehensive cell analysis

Feature Extraction

ConvNeXt Large

Modern CNN architecture with improved efficiency and performance

NASNet Large

Neural Architecture Search optimized network for automated feature learning

Hybrid Fusion

Intelligent combination of features from both architectures

Feature Selection

Z-score Normalization

Statistical normalization for feature standardization and improved convergence

mRMR Selection

Advanced feature selection based on relevance and redundancy criteria

Classification

Multi-Head Self-Attention

Transformer-inspired attention mechanism for robust classification

Grad-CAM Visualization

Explainable AI technique for visualizing important regions in classification

Model Performance Metrics

99.92%
Accuracy
Overall Correctness
95.89%
Sensitivity
True Positive Rate
99.64%
AUC Score
Area Under Curve
96.45%
Precision
Positive Predictive Value
98.74%
Specificity
True Negative Rate
96.14%
F1-Score
Harmonic Mean

Experience Our Algorithm in Action

Test our multi-stage deep learning approach with your own medical images or explore our sample dataset